Electrophysiology & Arrhythmia



Arrhythmia Mechanisms Revealed by Ripple Mapping

The introduction of cardiac electroanatomic mapping systems in the mid-1990s has permitted investigators to record intracardiac electrograms (EGMs) with accurate spatial localisation in 3D.1 These 3D mapping systems have enabled the display of the cardiac chambers as an anatomical shell upon which voltage, or activation, information can be displayed. Most commonly, colour is used to represent the variation of a single parameter that has been derived from the EGM at each sampled location.

Transvenous Lead Extractions: Current Approaches and Future Trends

The use of cardiovascular implantable electronic devices (CIEDs) has increased dramatically, with approximately 1.2–­1.4 million CIEDs implanted annually worldwide.1 In the US alone, there are more patients with CIEDs than registered nurses.2,3 CIEDs use leads that connect a generator to cardiac tissue to treat patients with many conditions including symptomatic bradycardia, morbid tachycardia and advanced heart failure.

Mechanisms Underlying the Actions of Antidepressant and Antipsychotic Drugs That Cause Sudden Cardiac Arrest

The link between sudden unexplained death in individuals with mental health problems who are administered antipsychotic drugs has been recognised for over a century.1 A clear relationship has emerged over the past 25 years between antipsychotic drugs, prolongation of the QT interval of the ECG, atypical polymorphic tachycardia known as torsade de pointes (TdP) and sudden cardiac death (SCD).

Heart Rate Variability: An Old Metric with New Meaning in the Era of using mHealth Technologies for Health and Exercise Training Guidance. Part One: Physiology and Methods

Considerable evidence supports the importance that the autonomic nervous system (ANS) has regarding cardiovascular health and prognosis.1 Specific variables derived from heart rate (HR) and heart rate variability (HRV) at rest and with exercise help assess the status of the ANS. Interest has also peaked on the use of HRV to assess the quality of an exercise programme. Among the athletic population, HRV has been recommended to warn of over-training and to optimise performance.

Arrhythmogenic Inflammatory Cardiomyopathy: A Review

Ventricular arrhythmias (VA) are commonly associated with structural heart disease and have substantial impact on patient outcomes and health system costs. Within the realm of cardiomyopathy (CM), there has been substantial progress with respect to ischaemic CM (ICM) in the understanding of infarct related scar biology and scar-mediated ventricular tachycardia (VT).