Mechanisms Underlying the Actions of Antidepressant and Antipsychotic Drugs That Cause Sudden Cardiac Arrest

The link between sudden unexplained death in individuals with mental health problems who are administered antipsychotic drugs has been recognised for over a century.1 A clear relationship has emerged over the past 25 years between antipsychotic drugs, prolongation of the QT interval of the ECG, atypical polymorphic tachycardia known as torsade de pointes (TdP) and sudden cardiac death (SCD).

Risk Stratification in Brugada Syndrome: Current Status and Emerging Approaches

Brugada syndrome (BrS) remains one of the most common inherited channelopathies associated with an increased risk of sudden cardiac death (SCD), with a worldwide prevalence of approximately 0.05 %.1–3 It is accepted that appropriate utilisation of the ICD in high-risk patients with aborted SCD and haemodynamically compromising arrhythmias is life-saving.

Brugada Syndrome and Early Repolarisation: Distinct Clinical Entities or Different Phenotypes of the Same Genetic Disease?

General understanding of early repolarisation (ER) has dramatically changed in the last decade. For several years, ER has been considered a benign electrocardiographic (ECG) finding with high prevalence in the general population. Recently different studies have challenged this view and showed a significant association with life-threatening arrhythmias.1–5

Bridging the Knowledge Gaps in Arrhythmogenic Cardiovascular Conditions: The Critical Role of Registries

One of the fundamental principles of evidence-based medicine is that clinical care should be based on data derived from appropriately designed trials, registries, and observational data from patients. The best available evidence is then used to develop guidelines for clinical care, assess quality, measure performance, and improve patient outcomes. The highest level of evidence in clinical medicine, also known as Level of Evidence A, is derived from multiple prospective randomized clinical trials (RCTs) or from meta-analysis.