Ventricular Fibrillation

Top 10 in Cardiology & Simple Education partnership

The Top 10 in Cardiology / Simple Partnership:

In March 2016, Simple Education and The Top 10 in Cardiology entered into a unique partnership where selected Top 10 in Cardiology content would be hosted on the Simple Education platform, we are pleased to introduce you to this world class content and this innovative medical education platform that is truly a leap forwards in how medical education is delivered.

Top 10 in Cardiology 2015:

Arrhythmogenic Cardiomyopathy: Electrical and Structural Phenotypes

Arrhythmogenic cardiomyopathy (ACM) is usually referred to as arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).1A first historical description was made in 1736, whereas its first modern description dates back to 1982.2 Initially, ACM was thought to be an embryological malformation.3 Yet in recent years it became evident that the pathophysiology of an ongoing genetically determined myocardial atrophy did not fit the theory of a congenital myocardial aplasia.

Periodic Repolarisation Dynamics: A Natural Probe of the Ventricular Response to Sympathetic Activation

Experimental and clinical studies have demonstrated that enhanced sympathetic autonomic nervous system (SANS) activity can destabilise myocardial repolarisation,1–4 increasing vulnerability to developing fatal cardiac arrhythmias.5–8 Accordingly, assessment of SANS activity has always been a major goal for cardiac risk stratification methods.

Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis

Optimal cardiac function depends on appropriate rate and force of contraction, with specific cardiac regions having developed particular beat-to-beat properties depending on their individual functions. For example, isovolumetric contraction time is shorter in the right ventricle (RV) than in the left ventricle (LV). At the cellular level, cardiac function is regulated by regional cardiomyocyte electrophysiological and Ca2+- handling properties (see Figure 1).

Early Repolarisation Syndrome – New Concepts

Early repolarisation pattern is defined electrocardiographically by a distinct J wave or J-point elevation that is either a notch or a slur of the terminal part of the QRS entirely above the baseline, with or without ST-segment elevation. The peak of the notch or slur (Jp) should be ≥0.1 mV in two or more contiguous leads, excluding leads V1 to V2 (see Figure 1).1,2 Early repolarisation syndromes (ERS) refer to sudden cardiac death or documented VT/VF in individuals with an early repolarisation pattern.