Adherence to Antihypertensive and Lipid-lowering Therapy - Impact on Clinical Practice

According to data provided by the National Center for Health Statistics (NCHS), life expectancy in the US increased by six years between 1970 and 2000.1,2 Much of this increase can be attributed to reductions in mortality due to cardiovascular (CV) disease (CVD).2 Similarly, the incidence of CVD-related mortality and morbidity has been falling steadily across the EU since the early 1980s, in contrast to some countries in Eastern Europe.3 Despite this reduction in CVD-related mortality rates, CVD remains the main cause of death in Europe today, accounting for

Preclinical Diagnosis and Risk Assessment of Atherosclerosis - At Birth? At Event? When is Best?

The endothelium, which was initially considered to be a semipermeable barrier separating lumen from vessel wall, is now recognised as a complex endocrine organ responsible for a variety of physiological processes vital for vascular homeostasis. These include the regulation of vascular tone, luminal diameter and blood flow; haemostasis and thrombolysis; platelet and leucocyte vessel-wall interactions; the regulation of vascular permeability; and tissue growth and remodelling.

Risk Reduction Strategies for Sudden Cardiac Death in Acute Myocardial Infarction

Sudden cardiac death (SCD) remains a public health problem of immense magnitude, afflicting an estimated 300,000 persons per year in the US.1 SCD, defined as death occurring within one hour from symptom-onset, is associated with ischemic heart disease in 80% of cases. Approximately one-third of cases are the result of an acute occlusion of an epicardial coronary artery.2 Some 50% of the mortality in acute myocardial infarction (AMI) is the result of sudden death.

Cardiovascular Disparities - Bridging Cardiovascular Health Promotion

The changing population landscape in the US has impacted the many levels of the US healthcare system. It is estimated that, by 2050, minority populations together will comprise approximately 50% of the total population.1 This demographic shift has prompted policy makers, scientists, researchers, educators, and healthcare providers to draft a series of national health initiatives to define, identify, and analyze healthcare disparities and inequities in order to restructure the healthcare system to the meet the challenges of such a culturally diverse.