Stem Cells

Cell Therapy - A 21st Century Hope for Treating Cardiovascular Disease - A Five-year Retrospective and Predictive View

Predicting the future of any innovative treatment is always risky and yet most of the predictions that were made in 2006 with regards to cell therapy have come to fruition. Let us look at where we were and where we are now. In 2006, we had moved from the idea of cell therapy through a number of preclinical models into early clinical applications, using a number of cell types, yet we were iterating between clinical application and unanswered basic questions. There were a huge number of unmet clinical needs and straightforward questions that had not been answered.

Breakthrough Regenerative Cardiopoietic Stem Cells and Related Technologies in the Field of Cardiovascular Medicine - From Bench to Bedside

Cardiovascular disease (CVD) is the largest cause of mortality in the world, before cancer and infectious diseases. World Health Organization statistics for 2008 show that close to one in three deaths (29 %) in the world is due to CVD, representing more than 17 million per year. Cardiac diseases represent around 60 % of CVDs and are the single largest cause of death in the CVD population.

Stem Cells in Cardiac Repair - Recent Developments and Future Directions

Myocardial infarction (MI) is the leading cause of death among people in the industrialised world and will, according to the World Health Organization (WHO), become the leading cause of death in the world in 2020.1 For the treatment of patients with MIs and ischaemic cardiomyopathies, remarkable medical advances have been made during the second half of the 20th Century that have increased patient survival.

Cardiovascular Medicine and Surgery in 2011 and Beyond

Five years ago, we were asked to speculate on the changes that could be expected to occur in cardiovascular treatment between 2006 and 2011. In the current article, we retrospectively examine our predictions and describe the current status of cardiovascular medicine and surgery in 2011. As we predicted, this field has continued to build on earlier breakthroughs in interventional heart valve replacement, regenerative myocardial therapy, myocardial revascularization, and mechanical circulatory support.